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KMID : 0360319940260050764
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 5 p.764 ~ p.769
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p53 Expression in Breast Cancer -Comparison between primary and metastatic lesions-
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황태숙
김영배/주영채/김준미/조경자/장자준
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Abstract
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Accumulation of mutated p53 protein in paired primary breast cancers and their metastatic axillary lymph node lesions are evaluated by immunohistochemical method to compare the difference between primary and metastatic foci.
Among 75 cases, 19 cases showed increased p53 expression and 1 case showed decreased expression in metastatic foci compared to the primary foci.
This nuclear protein was expressed only in the nuclei of the neoplastic cells except for one case which showed positive reaction in the nuclei of the hyperplastic ductal epithelium. This oncoprotein was expressed heterogenously in both primary
and
metastatic foci and appeared to be distributed more prominently in the invasive margins.
We concluded : 1) mutated p53 protein expression is heterogenously distributed 2) this mutated p53 protein expression was more frequent and increased in metastatic foci than primary foci 3) p53 gene mutation may be involved in breast cancer
progression
and evolution of metastatic subclone.
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KEYWORD
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